Seiji Shioda Selected Research

Pituitary Adenylate Cyclase-Activating Polypeptide Receptors

11/2014	Comparison of expression and proliferative effect of pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors on human astrocytoma cell lines.
1/2013	Expression and distribution of pituitary adenylate cyclase-activating polypeptide receptor in reactive astrocytes induced by global brain ischemia in mice.
11/2012	IL-6 and PACAP receptor expression and localization after global brain ischemia in mice.
1/2011	Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates proliferation of reactive astrocytes in vitro.
7/2006	Pleiotropic functions of PACAP in the CNS: neuroprotection and neurodevelopment.
4/2004	[Prevention of delayed neuronal cell death by PACAP and its molecular mechanism].

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Seiji Shioda Research Topics

Disease

23	Ischemia 06/2016 - 06/2002
14	Body Weight (Weight, Body) 01/2019 - 09/2005
11	Brain Ischemia (Cerebral Ischemia) 01/2021 - 01/2002
11	AIDS-Related Complex (ARC) 04/2010 - 10/2002
9	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2019 - 09/2005
9	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 03/2015 - 03/2003
8	Inflammation (Inflammations) 01/2022 - 08/2002
7	Neoplasms (Cancer) 11/2021 - 11/2003
7	Obesity 01/2018 - 05/2008
6	Insulin Resistance 01/2018 - 05/2003
6	Brain Injuries (Brain Injury) 06/2016 - 01/2002
6	Wounds and Injuries (Trauma) 10/2015 - 04/2004
6	Infarction (Infarctions) 01/2015 - 03/2003
5	Stroke (Strokes) 01/2020 - 05/2007
4	Spinal Cord Injuries (Spinal Cord Injury) 02/2015 - 04/2012
3	Dry Eye Syndromes (Dry Eye Syndrome) 01/2022 - 01/2016
3	Atherosclerosis 01/2022 - 08/2009
3	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 08/2012
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 12/2002
3	Narcolepsy 01/2019 - 04/2005
3	Hypertrophy 01/2018 - 01/2004
3	Hyperglycemia 12/2017 - 01/2017
3	Neurodevelopmental Disorders 04/2015 - 03/2005
3	Ganglion Cysts (Ganglion) 10/2013 - 07/2006
2	Glucose Intolerance 01/2022 - 04/2020
2	Mental Disorders (Mental Disorder) 11/2021 - 10/2012
2	Necrosis 11/2021 - 10/2011
2	Asthma (Bronchial Asthma) 11/2020 - 10/2018
2	Fatty Liver 04/2020 - 11/2016
2	Sleep Wake Disorders 01/2019 - 01/2016
2	Neoplasm Metastasis (Metastasis) 01/2017 - 07/2014
2	Weight Loss (Weight Reduction) 01/2017 - 07/2004
2	Parkinson Disease (Parkinson's Disease) 03/2015 - 12/2013
2	Ischemic Stroke 03/2015 - 11/2006
2	Pain (Aches) 02/2015 - 10/2003
2	Hypoxia (Hypoxemia) 02/2013 - 01/2012
2	Contusions 11/2012 - 07/2010
2	Central Nervous System Diseases (CNS Diseases) 04/2012 - 03/2005
2	Cerebral Infarction 03/2012 - 01/2002
2	Optic Nerve Injuries 01/2012 - 11/2008
2	Rheumatoid Arthritis 10/2011 - 03/2007
2	Cardiovascular Diseases (Cardiovascular Disease) 06/2011 - 12/2006
2	Arthritis (Polyarthritis) 03/2010 - 03/2007
2	T-Cell Leukemia (Leukemia, T Cell) 03/2010 - 03/2007

Drug/Important Bio-Agent (IBA)

41	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 01/2022 - 08/2002
14	OrexinsIBA 01/2019 - 04/2003
11	Peptides (Polypeptides)IBA 01/2020 - 05/2003
10	NeuropeptidesIBA 01/2022 - 04/2005
10	Messenger RNA (mRNA)IBA 01/2013 - 10/2002
8	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 03/2004
8	DNA (Deoxyribonucleic Acid)IBA 11/2021 - 11/2003
8	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2002
8	LeptinIBA 01/2017 - 05/2003
8	Neuroprotective AgentsIBA 10/2015 - 08/2002
6	Galanin-Like PeptideIBA 01/2018 - 03/2005
6	Pituitary Adenylate Cyclase-Activating Polypeptide ReceptorsIBA 11/2014 - 04/2004
5	EdaravoneIBA 01/2013 - 01/2002
5	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 07/2010 - 05/2003
5	Neuropeptide YIBA 06/2005 - 05/2003
4	Pharmaceutical PreparationsIBA 01/2020 - 01/2002
4	LipidsIBA 10/2018 - 11/2016
4	Therapeutic UsesIBA 01/2018 - 02/2009
4	Interleukin-1 (Interleukin 1)IBA 12/2013 - 06/2002
4	Interleukin-6 (Interleukin 6)IBA 11/2012 - 04/2004
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2010 - 09/2004
3	NucleoproteinsIBA 11/2021 - 03/2010
3	Insulin (Novolin)FDA Link 01/2017 - 05/2003
3	Saline SolutionIBA 01/2015 - 11/2012
3	AntioxidantsIBA 11/2014 - 02/2007
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 07/2013 - 11/2002
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2010 - 01/2002
3	Dihydrotachysterol (AT 10)IBA 07/2010 - 01/2008
3	GhrelinIBA 01/2008 - 09/2003
3	Cytochromes c (Cytochrome c)IBA 08/2007 - 05/2006
2	Apolipoproteins E (ApoE)IBA 01/2022 - 11/2014
2	Streptozocin (Streptozotocin)FDA Link 01/2022 - 01/2017
2	Type I Pituitary Adenylate Cyclase-Activating Polypeptide ReceptorsIBA 11/2020 - 09/2005
2	Nerve Growth Factors (Neurotrophins)IBA 01/2020 - 12/2002
2	AdiponectinIBA 01/2018 - 05/2014
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2017 - 10/2003
2	Bromodeoxyuridine (BrdU)IBA 06/2016 - 04/2015
2	NADPH Oxidases (NAD(P)H oxidase)IBA 11/2014 - 07/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2014 - 11/2006
2	Superoxides (Superoxide)IBA 11/2014 - 07/2010
2	Leptin ReceptorsIBA 11/2014 - 04/2003
2	Glial Fibrillary Acidic ProteinIBA 01/2013 - 10/2008
2	salicylhydroxamic acid (SHAM)IBA 11/2012 - 07/2009
2	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 10/2012 - 08/2007
2	CytokinesIBA 04/2012 - 07/2005
2	Oxygen (Dioxygen)IBA 03/2012 - 01/2002
2	Retinaldehyde (Retinal)IBA 01/2012 - 01/2011
2	Peroxynitrous Acid (Peroxynitrite)IBA 07/2010 - 03/2003
2	Hormones (Hormone)IBA 08/2009 - 05/2003
2	Free RadicalsIBA 05/2008 - 01/2002
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 12/2006 - 11/2004

Therapy/Procedure

4	Aftercare (After-Treatment) 10/2011 - 09/2005
2	Induced Hypothermia 01/2020 - 01/2013
2	Therapeutics 01/2020 - 01/2013
2	Intranasal Administration 01/2017 - 01/2016
2	Lasers (Laser) 11/2012 - 01/2010